01 - Combine buttermilk and hot sauce in a large bowl. Add chicken pieces and turn to coat thoroughly. Cover the bowl and refrigerate for at least 2 hours or overnight for optimal flavor penetration.
02 - Preheat oven to 450°F. Whisk flour, baking powder, baking soda, and salt in a large bowl. Cut in cold butter using a pastry blender or fingers until mixture resembles coarse crumbs. Pour in buttermilk and stir just until combined. Do not overmix.
03 - Turn dough onto a floured surface and gently pat to 3/4-inch thickness. Fold dough over itself 2-3 times to create flaky layers, then pat out again. Cut biscuits using a 2.5-inch round cutter and place on a parchment-lined baking sheet.
04 - Bake for 12–15 minutes until golden brown. Brush tops with honey or melted butter immediately after removing from oven if desired.
05 - Combine flour, paprika, garlic powder, onion powder, cayenne pepper, salt, and black pepper in a large bowl. Remove chicken from marinade, allowing excess liquid to drip off.
06 - Coat each chicken piece thoroughly in the seasoned flour mixture, pressing gently to adhere the coating. Shake off excess flour.
07 - Heat 1.5 inches of vegetable oil in a deep skillet or Dutch oven to 350°F. Fry chicken in batches without overcrowding, turning occasionally, until golden brown and cooked through to an internal temperature of 165°F, about 12–15 minutes per batch. Drain on a wire rack or paper towels.
08 - Serve warm fried chicken alongside hot buttermilk biscuits. Pair with honey butter, coleslaw, or mashed potatoes for a complete Southern meal.