01 - Whisk together buttermilk and hot sauce in a large bowl. Add chicken pieces, coating thoroughly. Cover and refrigerate for at least 4 hours or overnight for optimal flavor penetration.
02 - Combine flour, baking powder, baking soda, sugar, and salt in a large bowl. Cut in cold butter using a pastry cutter or fork until mixture resembles coarse crumbs. Add cold buttermilk and mix just until dough comes together. Turn onto a floured surface, gently pat to 3/4-inch thickness. Fold dough in half and pat out again; repeat this folding process twice to create flaky layers.
03 - Cut biscuits using a 2-inch round cutter. Place on parchment-lined baking sheet, positioning them close together for soft sides. Brush tops with additional buttermilk. Bake at 425°F for 12–15 minutes until golden brown. Cool slightly before serving.
04 - Mix flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne in a shallow dish. Remove chicken from marinade, allowing excess liquid to drip off. Dredge each piece in seasoned flour, pressing firmly to adhere coating. Let coated chicken rest on a rack for 10 minutes to set the breading.
05 - Heat 1–2 inches of vegetable oil in a large, heavy skillet or Dutch oven to 350°F. Fry chicken in batches without overcrowding, turning occasionally, until golden brown and cooked through—approximately 15–18 minutes for dark meat and 12–15 minutes for white meat. Transfer to a wire rack or paper towels to drain.
06 - Plate hot fried chicken alongside warm, flaky buttermilk biscuits. Serve with honey, hot sauce, or homemade gravy if desired.